To unlock all cheats, enter "AUNTMAY" at the code entry screen.

To unlock Debug Mode, enter "DRILHERE" at the code entry screen.

To choose any level in the game, enter "NONJYMNT" at the code entry screen.

To unlock all of Webhead's costumes, enter "WASHMCHN" at the code entry screen.

To unlock all of the stuff in the gallery, enter "DRKROOM" at the code entry screen.

To unlock all of the Training Challenges in the game, enter "CEREBRA" at the code entry screen.

To unlock Big Head Mode, enter "ALIEN" as a code at the code entry screen.

To unlock Big Feet Mode enter "STACEYD" at the code entry screen.

To unlock What If? Mode, enter "VVISIONS" at the code entry screen.

To see how well the programmers did playing these games, enter "VVHISCRS" at the code entry screen.

Beat the game twice on Normal to unlock the Amazing Bag Man, Ben Reilly, Captain Universe, Peter Parker, Quick Change Spidey, and Scarlet Spidey Costumes.

To unlock the Spidey Phoenix costume, beat the game on Hard.

Beat the game on Easy to unlock the Venom and Symbiote Spider costumes.